siglec 10; siglec-10; siglec10; Sialic acid-binding Ig-like lectin 10; Siglec-like protein 2; SLG2
Supplied as 0.22um filtered solution in 20mM PB, 150mM Nal, 25mM Arginine(pH 7.4).
The product should be stored at -70℃. Please do not repeated freeze-thaw cycles.
Recombinant Siglec-10 on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%.
The purity of Siglec-10 is greater than 95% as determined by SEC-HPLC.
Immobilized human Siglec-10 at 0.5ug/ml(100ul/well). Dose response curve for Anti-Siglec10 with the EC50 of 8.6ng/ml determined by ELISA.
Siglec-10 is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab. It is also reported to bind to Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24 also known as HSA (Heat-stable antigen).Siglecs (sialic acid binding Ig-like lectins) are I-type lectins that belong to the immunoglobulin superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by a varying number of Ig-like C2-type domains. Siglecs 5-11 constitute the CD33/Siglec-3 related group, and are differentially expressed in the hematopoietic system.