ALK-HM407B-100μg / 询价
ALK-HM407B-500μg / 询价
ALK-HM407B-500μgx2 / 询价
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Biotinylated Human ALK-7/Activin RIC Protein
Recombinant Biotinylated Human ALK-7/Activin RIC Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus.It contains Glu21-Glu113 [Accession | Q8NER5-1].
The protein has a predicted MW of 13.71 kDa. Due to glycosylation, the protein migrates to 20-40 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 90% as determined by HPLC
Less than 1 EU per μg by the LAL method.
Lyophilized from 0.22 μm filtered solution in 20mM Tris, 150mM NaCl (pH 7.5). Normally 8% trehalose is added as protectant before lyophilization.
Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Arterial stiffness is an important feature of diabetic macrovascular complications. Activin receptor-like kinase 7 (ALK7), a member of type I transforming growth factor-β (TGF-β) receptors, is correlated with pathogenic risks of type 2 diabetes mellitus and cardiovascular diseases and may be involved in cardiovascular remodeling.
ACTR-IC; ACVR1C; ALK7; Activin R1C;
Li WB, Zhao J, Liu L, Wang ZH, Han L, Zhong M, Zhang Y, Zhang W, Tang MX. Silencing of activin receptor-like kinase 7 alleviates aortic stiffness in type 2 diabetic rats. Acta Diabetol. 2015 Aug;52(4):717-26. doi: 10.1007/s00592-014-0706-8. Epub 2015 Jan 11. PMID: 25577243.
