CD9-HM498B-100μg / 询价
CD9-HM498B-500μg / 询价
CD9-HM498B-500μgx2 / 询价
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Biotinylated Human CD98 Protein
Recombinant Biotinylated Human CD98 Protein is expressed from HEK293 with His tag and Avi tag at the N-terminus.It contains Arg206-Ala630 [Accession | AAH01061].
The protein has a predicted MW of 49.75 kDa. Due to glycosylation, the protein migrates to 50-65 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 90% as determined by HPLC
Less than 1 EU per μg by the LAL method.
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
The type II transmembrane protein CD98, best known as the heavy chain of the heterodimeric amino acid transporters (HAT), is required for the surface expression and basolateral localization of this transporter complex in polarized epithelial cells. CD98 also interacts with beta1 integrins resulting in an increase in their affinity for ligand. In this study we explored the role of the transmembrane and cytoplasmic domains of CD98 on integrin-dependent cell adhesion and migration in polarized renal epithelial cells.
4F2hc; CD98; SLC3A2; 4F2; CD98HC; MDU1; NACAE; 4T2HC
(1) Cai S, Bulus N, Fonseca-Siesser PM, Chen D, Hanks SK, Pozzi A, Zent R. CD98 modulates integrin beta1 function in polarized epithelial cells. J Cell Sci. 2005 Mar 1;118(Pt 5):889-99. doi: 10.1242/jcs.01674. Epub 2005 Feb 15. PMID: 15713750.
