货号价格

5T4-HM401F-100μg / 询价

5T4-HM401F-500μg / 询价

5T4-HM401F-500μgx2 / 询价

FITC-Labeled Human TPBG/5T4 Protein

产品信息(Product Info)
表达区间及表达系统(Source)

Recombinant FITC-Labeled Human TPBG/5T4 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.
It contains Ser32-Ser355 [Accession | Q13641-1].

分子量大小(Molecular Weight)

The protein has a predicted MW of 38.2 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Bis-Tris PAGE result.

波长(Wavelength)

Excitation Wavelength: 490 nm

Emission Wavelength: 520 nm

纯度(Purity)

> 95% as determined by Bis-Tris PAGE

内毒素(Endotoxin)

Less than 1EU per μg by the LAL method.

制剂(Formulation)

Supplied as 0.22μm filtered solution in PBS (pH 7.4).

存储(Storage)

Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

产品数据(Assay Data)
Bis-Tris PAGE

FITC-Labeled Human TPBG on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

背景(Background)

The oncofetal tumor-associated antigen 5T4 (TBGP) has been linked with CSC properties in several different malignancies. 5T4 has functional attributes that are relevant to the spread of tumors including through EMT, CXCR4/CXCL12, Wnt, and Hippo pathways which may all contribute through the mobilization of CSCs.

分子别名(Synonyms)

M6P1; 5T4AG; WAIF1; TPBG; 5T4

文献(References)

(1) Harrop R, O'Neill E, Stern PL. Cancer stem cell mobilization and therapeutic targeting of the 5T4 oncofetal antigen. Ther Adv Vaccines Immunother. 2019 Jan 25;7:2515135518821623. doi: 10.1177/2515135518821623. PMID: 30719508; PMCID: PMC6348545.