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Fc受体蛋白
FcR是免疫球蛋白Ig的受体，可通过与Ig的Fc段特定区域结合引起相应的细胞特异性免疫反应，起着连接机体体液免疫和细胞免疫的桥梁作用。FcR的基因多态性使其能引起多样的细胞内生物效应，而这又与多种免疫相关疾病的发生发展密切相关，如自身免疫病SLE和RA。 Fc受体蛋白是免疫系统最为重要的蛋白家族之一，介导了抗体依赖的ADCP、ADCC及CDC效应，在免疫系统激活及抗体作用发挥中起到关键作用。
目前应用最广泛的主要是IgG受体，包括FcRn和FcγR。FcγR可分为三类：FcγRI，FcγRII和FcγRIII。FcγRI与IgG具有高亲和力(10-9M)，主要表达于单核巨噬细胞。FcγRII、FcγRIII与IgG具有低亲和力(10-6M)，分布比较广泛。FcγRII根据胞质区的结构不同，又分为FcγRIIa、FcγRIIb和FcγRIIc 3种类型，存在于B细胞、巨噬细胞、多形核细胞、血小板及单核细胞，且FcγRIIb是唯一抑制型受体。FcγRIII存在于粒细胞、NK细胞、巨噬细胞及活化的单核细胞。FcγR与抗体结合可以起到激活免疫细胞并产生内吞、吞噬、ADCC等作用。
人Fcγ受体结构图（DOI: 10.1016/j.jaci.2020.06.036）
FcRn可以在酸性小泡内(pH < 7.0)和IgG结合，保护抗体大分子不被破坏；然后在pH等于7.4的血液环境下，释放抗体大分子，如此可延长抗体的半衰期，这对抗体的药效发挥有重要作用。
FcRn延长IgG半衰期的机制（DOI: 10.1038/nri2155）
恺佧生物基于对Fc受体蛋白的深入理解，并通过自己独有的蛋白研发生产平台SAMSTM成功研制出一系列高质量Fc受体重组蛋白产品，包括FcRn和FcγR的多种亚型及其突变形式，可实现抗体Fc区域的功能验证，适合多种分析方法，助力抗体药研发。
数据示例
Immobilized Human FcRn, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-FcRn Antibody, hFc Tag with the EC50 of 5.4 ng/ml determined by ELISA (QC Test).
Human FcRn, His Tag captured on CM5 Chip via anti-his antibody can bind Human IgG1 Fc, No Tag with an affinity constant of 0.28 μM as determined in SPR assay (QC Test).
Immobilized Human Fc gamma RIIIA (F176) , His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-Fc gamma RIIIA Antibody, hFc Tag with the EC50 of 10.1 ng/ml determined by ELISA (QC Test).
Human Fc gamma RIIIA (F176) , His Tag captured on CM5 Chip via anti-His antibody can bind Rituximab, hFc Tag with an affinity constant of 0.92 μM as determined in SPR assay (QC Test).
产品列表
| 货号 | 蛋白名称 | 种属 | 标签 | 表达体系 | |
|---|---|---|---|---|---|
| FRI-HM464 | Fc gamma RI / CD64 | Human | C-His-Avi | HEK293 | 立即询价 |
| FRI-HM464B | Biotinylated Fc gamma RI / CD64 | Human | C-His-Avi | HEK293 | 立即询价 |
| FRI-MM164 | Fc gamma RI / CD64 | Mouse | C-His | HEK293 | 立即询价 |
| FRI-RM164 | Fc gamma RI / CD64 | Rat | C-His | HEK293 | 立即询价 |
| CDA-HM432 | Fc gamma RIIA / CD32a (H167) | Human | C-His-Avi | HEK293 | 立即询价 |
| CDA-HM432-UL | Fc gamma RIIA / CD32a (H167), Ultra Low Endotoxin | Human | C-His-Avi | HEK293 | 立即询价 |
| CDA-HM432B | Biotinylated Fc gamma RIIA / CD32a (H167) | Human | C-His-Avi | HEK293 | 立即询价 |
| FCR-HM42A | Fc gamma RIIA / CD32a (R167) | Human | C-His-Avi | HEK293 | 立即询价 |
| FCR-HM42AB | Biotinylated Fc gamma RIIA / CD32a （R167） | Human | C-His-Avi | HEK293 | 立即询价 |
| CDA-CM132 | Fc gamma RIIA / CD32a | Cynomolgus | C-His | HEK293 | 立即询价 |
| CDB-HM401 | Fc gamma RIIB/C (CD32b/c) | Human | C-His-Avi | HEK293 | 立即询价 |
| CDB-HM401-UL | Fc gamma RIIB/C (CD32b/c), Ultra Low Endotoxin | Human | C-His-Avi | HEK293 | 立即询价 |
| CDB-HM401B | Biotinylated Fc gamma RIIB/C (CD32b/c) | Human | C-His-Avi | HEK293 | 立即询价 |
| CDB-CM101 | Fc gamma RIIB | Cynomolgus | C-His | HEK293 | 立即询价 |
| CDB-MM101 | Fc gamma RIIB / CD32b | Mouse | C-His | HEK293 | 立即询价 |
| FGR-CM1R3 | Fc gamma RIII / CD16 | Cynomolgus | C-His | HEK293 | 立即询价 |
| FGR-CM1R3-UL | Fc gamma RIII / CD16, Ultra Low Endotoxin | Cynomolgus | C-His | HEK293 | 立即询价 |
| FGR-CM4R3B | Biotinylated Fc gamma RIII / CD16 | Cynomolgus | C-His-Avi | HEK293 | 立即询价 |
| FGR-MM1R3 | Fc gamma RIII / CD16 | Mouse | C-His | HEK293 | 立即询价 |
| FGR-MM4R3B | Fc gamma RIII / CD16 | Mouse | C-His-Avi | HEK293 | 立即询价 |
| FCR-HM13A | Fc gamma RIIIA / CD16a (V176) | Human | C-His | HEK293 | 立即询价 |
| FCR-HM43AB | Biotinylated Fc gamma RIIIA / CD16a (V176) | Human | C-His-Avi | HEK293 | 立即询价 |
| FCR-HM31D | Fc gamma RIIIA / CD16a (V176) | Human | C-mFc | HEK293 | 立即询价 |
| CDA-HM416 | Fc gamma RIIIA / CD16a (F176) | Human | C-His-Avi | HEK293 | 立即询价 |
| CDA-HM416B | Biotinylated Fc gamma RIIIA / CD16a (F176) | Human | C-His-Avi | HEK293 | 立即询价 |
| FCR-HM11B | Fc gamma RIIIB / CD16b (NA1) | Human | C-His | HEK293 | 立即询价 |
| FCR-HM41BB | Biotinylated Fc gamma RIIIB / CD16b (NA1) | Human | C-His-Avi | HEK293 | 立即询价 |
| FCR-HM42B | Fc gamma RIIIB /CD16b(NA2) | Human | C-His-Avi | HEK293 | 立即询价 |
| FCR-HM42BB | Biotinylated Fc gamma RIIIB / CD16b | Human | C-His-Avi | HEK293 | 立即询价 |
| FCR-MM162 | Fc gamma RIV / CD16-2 | Mouse | C-His | HEK293 | 立即询价 |
| FRN-HM101 | FcRn | Human | C-His | HEK293 | 立即询价 |
| FRN-HM401B | FcRn | Human | C-His-Avi | HEK293 | 立即询价 |
| FRN-MM101 | FcRn | Mouse | C-His | HEK293 | 立即询价 |
| FRN-MM401B | FcRn | Mouse | C-His-Avi | HEK293 | 立即询价 |
| FRN-CM101 | FcRn | Cynomolgus | C-His | HEK293 | 立即询价 |
| FRN-CM401B | FcRn | Cynomolgus | C-His-Avi | HEK293 | 立即询价 |
| FRN-RM101 | FcRn | Rat | C-His | HEK293 | 立即询价 |
| FRN-RM401B | FcRn | Rat | C-His-Avi | HEK293 | 立即询价 |
| FER-HM101 | Fc epsilon RI alpha / FCER1a | Human | C-His | HEK293 | 立即询价 |
| FER-HM201 | Fc epsilon RI alpha / FCER1a | Human | C-hFc | HEK293 | 立即询价 |
| FER-HM201-UL | Fc epsilon RI alpha / FCER1a, Ultra Low Endotoxin | Human | C-hFc | HEK293 | 立即询价 |
| FER-MM201 | Fc epsilon RI alpha / FCER1a | Mouse | C-hFc | HEK293 | 立即询价 |
| CD3-HM123 | Fc epsilon RII / CD23 | Human | N-His | HEK293 | 立即询价 |
| CD3-HM123B | Biotinylated Fc epsilon RII / CD23 | Human | N-His-Avi | HEK293 | 立即询价 |
| IGG-HM001 | IgG1 Fc | Human | No Tag | HEK293 | 立即询价 |
| IGG-HM001-UL | IgG1 Fc, Ultra Low Endotoxin | Human | No Tag | HEK293 | 立即询价 |
| MFC-MM001 | IgG1 Fc | Mouse | No Tag | HEK293 | 立即询价 |
| IGG-HM004 | IgG4 Fc | Human | No Tag | HEK293 | 立即询价 |
| IGG-HM004-UL | IgG4 Fc, Ultra Low Endotoxin | Human | No Tag | HEK293 | 立即询价 |
