IGG-HM004-100μg / 询价
IGG-HM004-500μg / 询价
IGG-HM004-500μgx2 / 询价
Human IgG4 Fc Protein
Recombinant Human IgG4 Fc Protein is expressed from HEK293 without tag.It contains Glu99-Gly326 [Accession | P01861].
The protein has a predicted MW of 25.8 kDa. Due to glycosylation, the protein migrates to 30-35 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Less than 1EU per μg by the LAL method.
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human IgG4 Fc on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human IgG4 Fc is greater than 95% as determined by SEC-HPLC.
Human FcRn, His Tag captured on CM5 Chip via Anti-His Antibody can bind Human IgG4 Fc, No Tag with an affinity constant of 1.365 μM as determined in SPR assay (Biacore T200).
It is known as a IgG4-related disease and its differentiation is based on the analysis of IgG4 levels in the affected tissues. The IgG4-related disease is considered to be a generalized pathological process involving a wide spectrum of various disorders that may affect distant organs.
IGHG4
(1)Touzani F, Pozdzik A. New insights into immune cells cross-talk during IgG4-related disease. Clin Immunol. 2019;198:1-10. doi:10.1016/j.clim.2018.11.004
