AB26 | 价格

AB26-1mg / 询价

Anti-MASP2 Antibody (Narsoplimab Biosimilar)

产品信息(Product Info)
反应种属(Reactivities)

Huma/Cynomolgus/Mouse/Rat

靶点(Target)

MASP2

同型(Isotype)

Human IgG1-Kappa

标记(Conjugation)

Unconjugated

纯化(Purification)

protein A

无菌(Sterility)

0.2 μM filtered

制剂(Formulation)

PBS, 10% glycerol (pH 7.4)

内毒素(Endotoxin)

Less than 1 EU per μg by the LAL method.

稀释缓冲液
(Recommended Dilution Buffer)

PBS (pH 7.4), contains no stabilizers or preservatives.

纯度(Purity)

<p style="line-height: 25px;">> 95% as determined by Bis-Tris PAGE<br />> 95% as determined by HPLC</p>

存储(Storage)

<p style="line-height: 25px;">Valid for 12 months from date of receipt when stored at -80°C.<br />Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.</p>

应用(Applications)

ELISA/SPR

产品数据(Assay Data)
Bis-Tris PAGE
Narsoplimab Biosimilar on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
SEC-HPLC
The purity of Narsoplimab Biosimilar is greater than 95% as determined by SEC-HPLC.
ELISA Data
Immobilized Human MASP2, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Narsoplimab Biosimilar with the EC50 of 5.2ng/ml determined by ELISA. (QC Test)
背景(Background)

Te MASP2 gene is located on the chromosome 1p36.23–31 and encodes two proteins, MASP-2 and Map198. Both the levels and function of MASP-2 are modulated by the single-nucleotide polymorphisms (SNPs) of the MASP2 gene. Te level of MASP-2 in plasma plays a dual role in the infection and progression of infectious diseases. Te defciency of MASP-2 in plasma has been associated with the susceptibility of HIV. By contrast, the overproduction of MASP-2 may increase the infammatory efect.

文献(References)

Li Z, Wang M, Zhong H, Huang X, Wu X, Zhang X, Wang J, Deng J, Chen M, Chen L, Tan H. Impact of MASP2 gene polymorphism and gene-tea drinking interaction on susceptibility to tuberculosis. Sci Rep. 2021 Mar 22;11(1):6544. doi: 10.1038/s41598-021-86129-x. PMID: 33753877; PMCID: PMC7985323.