AB471 | 价格

AB471-1mg / 询价

Anti-Tissue Factor Antibody (Tisotumab Biosimilar)

产品信息(Product Info)
反应种属(Reactivities)

Human/Cynomolgus

靶点(Target)

Tissue Factor

同型(Isotype)

Human IgG1-Kappa

标记(Conjugation)

Unconjugated

纯化(Purification)

protein A

无菌(Sterility)

0.2 μM filtered

制剂(Formulation)

PBS, 10% glycerol (pH 7.4)

内毒素(Endotoxin)

Less than 1 EU per μg by the LAL method.

稀释缓冲液
(Recommended Dilution Buffer)

PBS (pH 7.4), contains no stabilizers or preservatives.

纯度(Purity)

<p style="line-height: 25px;">> 95% as determined by Bis-Tris PAGE<br />> 95% as determined by HPLC</p>

存储(Storage)

<p style="line-height: 25px;">Valid for 12 months from date of receipt when stored at -80°C.<br />Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.</p>

应用(Applications)

ELISA

产品数据(Assay Data)
Bis-Tris PAGE
Tisotumab Biosimilar on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
SEC-HPLC
The purity of Tisotumab Biosimilar is greater than 95% as determined by SEC-HPLC.
ELISA Data
Immobilized Human Tissue Factor, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Tisotumab Biosimilar with the EC50 of 4.4ng/ml determined by ELISA. (QC Test)
背景(Background)

Tissue factor (also named Coagulation Factor III) is a cell surface glycoprotein responsible for initiating the extrinsic pathway of coagulation.Tissue factor is the primary cellular initiator of blood coagulation via interaction with coagulation factor VII. Aberrant expression of tissue factor is responsible for thrombosis during septic shock, atherosclerosis and cancer.

文献(References)

(1) Rao LV. Tissue factor as a tumor procoagulant. Cancer Metastasis Rev. 1992 Nov;11(3-4):249-66. doi: 10.1007/BF01307181. PMID: 1423817.

(2) Carmeliet P, Collen D. Tissue factor. Int J Biochem Cell Biol. 1998 Jun;30(6):661-7. doi: 10.1016/s1357-2725(97)00121-0. PMID: 9695023.