BBL-HM241-100μg / 询价
BBL-HM241-500μg / 询价
BBL-HM241-500μgx2 / 询价
Human 4-1BB Ligand/TNFSF9 Trimer Protein
Recombinant Human 4-1BB Ligand/TNFSF9 Trimer Protein is expressed from HEK293 with monomeric hFc tag at the N-Terminus.It contains Arg71-Glu254 [Accession | P41273].
The protein has a predicted MW of 84.3 kDa same as Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
Less than 1EU per μg by the LAL method.
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human 4-1BB Ligand (Trimer) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human 4-1BB Ligand (Trimer) is greater than 95% as determined by SEC-HPLC.
Immobilized Human 4-1BB, His Tag at 1μg/ml (100μl/Well) on the plate. Dose response curve for Human 4-1BB Ligand Trimer, hFc Tag with the EC50 of 5.4ng/ml determined by ELISA (QC Test).
The 4-1BBL is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. 4-1BB ligand (4-1BBL) is an inducible molecule present on several APC types, including B cells, macrophages and DCs.4-1BB:4-1BBL pathway seems to amplify the existing costimulatory signals, even if the engagement of 4-1BB in the presence of a strong TCR signaling can induce IL-2 production in a CD28-independent manner.
41BB Ligand; 4-1BB Ligand; 4-1BBL; CD137L; TNFSF9
(1)Vinay D S , Kwon B S. 4-1BB (CD137), an inducible costimulatory receptor, as a specific target for cancer therapy[J]. BMB Reports, 2014, 47(3):122-129.
