货号价格

CCR-HM02B-100μg / 询价

CCR-HM02B-100μg x 5 / 询价

CCR-HM02B-100μg x 10 / 询价

Human CCR2b Protein-VLP

产品信息(Product Info)
表达区间及表达系统(Source)

Recombinant Human CCR2b Protein-VLP is expressed from HEK293. It contains Met1-Leu360.[Accession | P41597-2]

分子量大小(Molecular Weight)

The target protein has a predicted MW of 42.9kDa.

内毒素(Endotoxin)

Less than 1EU per μg by the LAL method.

纯度(Purity)

> 95% as determined by HPLC

制剂(Formulation)

Supplied as 0.22μm filtered solution in PBS (pH 7.4). Notice: If you need it for immunization, Do Not use any adjuvant.

存储(Storage)

Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

产品数据(Assay Data)
SEC-HPLC

The purity of Human CCR2b VLP is greater than 95% as determined by SEC-HPLC.

ELISA Data

Immobilized Human CCR2b VLP at 5μg/ml (100μl/Well) on the plate. Dose response curve for Anti-CCR2b Antibody, hFc Tag with the EC50 of 0.11μg/ml determined by ELISA.

背景(Background)

The chemokine (C-C motif) receptor 2B (CCR2B) is one of the two isoforms of the receptor for monocyte chemoattractant protein-1 (CCL2), the major chemoattractant for monocytes, involved in an array of chronic inflammatory diseases. The actin-binding protein filamin A (FLNa) as a protein that associates with the carboxyl-terminal tail of CCR2B. FLNa emerges as an important protein for controlling the internalization and spatial localization of the CCR2B receptor in different dynamic membrane structures.

分子别名(Synonyms)

C-C CKR-2; CCR-2; CCR2; MCP-1-R; CMKBR2; CCR2

文献(References)

(1) Minsaas L, Planagumà J, Madziva M, Krakstad BF, Masià-Balagué M, Katz AA, Aragay AM. Filamin a binds to CCR2B and regulates its internalization. PLoS One. 2010 Aug 17;5(8):e12212. doi: 10.1371/journal.pone.0012212. PMID: 20808917; PMCID: PMC2923182.