CCR-HM02B-100μg / 询价
CCR-HM02B-100μg x 5 / 询价
CCR-HM02B-100μg x 10 / 询价
Human CCR2b Protein-VLP
Recombinant Human CCR2b Protein-VLP is expressed from HEK293.It contains Met1-Leu360 [Accession | P41597-2].
The target protein has a predicted MW of 42.9kDa.
> 95% as determined by HPLC
Less than 1EU per μg by the LAL method.
Supplied as 0.22μm filtered solution in PBS, 300mM L-Arginine (pH 7.4). Notice: If you need it for immunization, water-soluble adjuvant is recommended.
Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
The purity of Human CCR2b VLP is greater than 95% as determined by SEC-HPLC.
Immobilized Human CCR2b VLP at 5μg/ml (100μl/Well) on the plate. Dose response curve for Anti-CCR2b Antibody, hFc Tag with the EC50 of 0.11μg/ml determined by ELISA.
The chemokine (C-C motif) receptor 2B (CCR2B) is one of the two isoforms of the receptor for monocyte chemoattractant protein-1 (CCL2), the major chemoattractant for monocytes, involved in an array of chronic inflammatory diseases. The actin-binding protein filamin A (FLNa) as a protein that associates with the carboxyl-terminal tail of CCR2B. FLNa emerges as an important protein for controlling the internalization and spatial localization of the CCR2B receptor in different dynamic membrane structures.
C-C CKR-2; CCR-2; CCR2; MCP-1-R; CMKBR2; CCR2
(1) Minsaas L, Planagumà J, Madziva M, Krakstad BF, Masià-Balagué M, Katz AA, Aragay AM. Filamin a binds to CCR2B and regulates its internalization. PLoS One. 2010 Aug 17;5(8):e12212. doi: 10.1371/journal.pone.0012212. PMID: 20808917; PMCID: PMC2923182.
