CCR-HM16NB-100μg / 询价
CCR-HM16NB-100μgx5 / 询价
CCR-HM16NB-100μgx10 / 询价
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Biotinylated Human CCR6 Nanodisc
Recombinant Biotinylated Human CCR6 Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Met374 [Accession | P51684].
The protein has a predicted MW of 55.4 kDa.
Less than 1 EU per μg by the LAL method.
Supplied as 0.22 μm filtered solution in PBS, 200mM L-Arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
Valid for 6 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized Biotinylated Human CCR6 Nanodisc, His Tag at 5μg/ml (100μl/well)on the streptavidin precoated plate (5μg/ml). Dose response curve for Anti-CCR6 Antibody, hFc Tag with the EC50 of 1.29μg/ml determined by ELISA. (QC Test)
Biotinylated Human CCR6 Nanodisc, His Tag captured on CM5 Chip via Streptavidin can bind Anti-CCR6 Antibody, hFc Tag with an affinity constant of 3.57 nM as determined in SPR assay (Biacore T200).
Loaded Biotinylated Human CCR6 Nanodisc, His Tag on Streptavidin-Biosensor can bind Anti-CCR6 Antibody, hFc Tag with an affinity constant of 2.28 nM as determined in BLI assay (Gator® Prime).
The CC chemokine receptor 6 (CCR6), a G protein-coupled receptor (GPCR) is an important receptor that is involved in regulating several aspects of mucosal immunity, including the ability to mediate the recruitment of immature dendritic cells (DCs) and mature DCs, and professional antigen presenting cells (APCs) to the sites of epithelial inflammation. Further, CCR6 mediates the homing of both CD4(+) T (T-helper; Th) cells and DCs to the gut mucosal lymphoid tissue.
C-C CKR-6; CC-CKR-6; CCR-6; CKR-L3; DRY6; DCR2; GPRCY4; LARC receptor; CD196; CKRL3, CMKBR6; GPR29; STRL22; BN-1
Ito T, Carson WF 4th, Cavassani KA, Connett JM, Kunkel SL. CCR6 as a mediator of immunity in the lung and gut. Exp Cell Res. 2011 Mar 10;317(5):613-9. doi: 10.1016/j.yexcr.2010.12.018. PMID: 21376174; PMCID: PMC3063449.
