CCR-HM16NB-100μg / 询价
CCR-HM16NB-100μgx5 / 询价
CCR-HM16NB-100μgx10 / 询价
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表达区间及表达系统(Source)
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Recombinant Biotinylated Human CCR6 Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Met374 [Accession | P51684]. |
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分子量大小(Molecular Weight)
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The protein has a predicted MW of 55.4 kDa. |
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内毒素(Endotoxin)
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Less than 1 EU per μg by the LAL method. |
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制剂(Formulation)
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Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells. |
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存储(Storage)
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Valid for 6 months from date of receipt when stored at -80°C. |
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阴性对照
(Recommended Negative Control)
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CON-HM1NB |
Our Styrene-Maleic Anhydride(SMA) nanodisc platform delivers multi-pass transmembrane proteins exactly as they exist in the HEK293 cell membrane following recombinant expression— preserving their endogenous lipid environment and correct conformational states. Isolated directly from HEK293 cells via a gentle, detergent-free process, the multi-pass membrane proteins are subsequently encapsulated by SMA to ensure their stability. These uniform soluble nanoparticles eliminate extraction interferences while maintaining biological activity. Ensuring consistent performance from lot to lot, our nanodiscs provide the reliability and biological relevance essential for antibody screening and functional characterization in therapeutic antibody drug discovery and development, as assessed by SPR, BLI, ELISA, and other standard platforms.
❖ Correct structure & conformation
❖ Functional relevance ensured
❖ His-tag & biotinylation tag available
❖ Antibody screening
❖ Functional characterization(Molecular Level)
❖ Assay: SPR, BLI, ELISA
Recombinant Biotinylated Human CCR6 Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Met374 [Accession | P51684].
The protein has a predicted MW of 55.4 kDa.
Less than 1 EU per μg by the LAL method.
Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
Valid for 6 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
The CC chemokine receptor 6 (CCR6), a G protein-coupled receptor (GPCR) is an important receptor that is involved in regulating several aspects of mucosal immunity, including the ability to mediate the recruitment of immature dendritic cells (DCs) and mature DCs, and professional antigen presenting cells (APCs) to the sites of epithelial inflammation. Further, CCR6 mediates the homing of both CD4(+) T (T-helper; Th) cells and DCs to the gut mucosal lymphoid tissue.
C-C CKR-6; CC-CKR-6; CCR-6; CKR-L3; DRY6; DCR2; GPRCY4; LARC receptor; CD196; CKRL3, CMKBR6; GPR29; STRL22; BN-1;C-C CKR6; CC-CKR6; CCR6; BN1
Ito T, Carson WF 4th, Cavassani KA, Connett JM, Kunkel SL. CCR6 as a mediator of immunity in the lung and gut. Exp Cell Res. 2011 Mar 10;317(5):613-9. doi: 10.1016/j.yexcr.2010.12.018. PMID: 21376174; PMCID: PMC3063449.
CCR-HM16NB-100μg / 询价
CCR-HM16NB-100μgx5 / 询价
CCR-HM16NB-100μgx10 / 询价
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