CD2-CM224B-100μg / 询价
CD2-CM224B-500μg / 询价
CD2-CM224B-500μgx2 / 询价
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Biotinylated Cynomolgus CD24 Protein (Primary Amine Labeling)
Recombinant Biotinylated Cynomolgus CD24 Protein (Primary Amine Labeling) is expressed from HEK293 with hFc tag at the C-Terminus.It contains Thr27-Lys54 [Accession | I7GKK1-1].
The protein has a predicted MW of 30.2 kDa. Due to glycosylation, the protein migrates to 50-58 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Less than 1EU per ug by the LAL method.
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Biotinylated Cynomolgus CD24 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Biotinylated Cynomolgus CD24 is greater than 95% as determined by SEC-HPLC.
CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential for targeting CD24 in cancer therapy seems promising, as CD24 is overexpressed in many human cancers.
CD 24; CD24 molecule; CD24A; FLJ22950; FLJ43543; MGC75043
(1)Barkal AA, et al.CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy.Nature. 2019 Jul 31. doi: 10.1038/s41586-019-1456-0.D
(2)Sun F, Wang T, Jiang J, et al. Engineering a high-affinity humanized anti-CD24 antibody to target hepatocellular carcinoma by a novel CDR grafting design[J]. Oncotarget, 2017, 8(31):51238-51252.
