CD33-HM1N144-100μg / 询价
CD33-HM1N144-100μg x 5 / 询价
CD33-HM1N144-100μg x 10 / 询价
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Human CD133 Protein-Nanodisc
Recombinant Human CD133 Protein-Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-His865 [Accession | O43490-1].
The protein has a predicted MW of 98.60 kDa.
Less than 1EU per μg by the LAL method.
Supplied as 0.22 μm filtered solution in PBS (pH 7.4). Notice: Not recommended for immunization.
Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized Human CD133 Nanodisc, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Anti-CD133 Antibody, hFc Tag with the EC50 of 4.4ng/ml determined by ELISA (QC Test).
Human CD133 Nanodisc, His Tag captured on CM5 Chip via Anti-His Antibody can bind Anti-CD133 Antibody with an affinity constant of 0.25 nM as determined in SPR assay (Biacore T200).
Prominin-1 (PROM1), also known as CD133, is expressed in hepatic progenitor cells (HPCs) and cholangiocytes of the fibrotic liver. It is a cell surface biomarker that allows the identification of stem and cancer stem cells from different organs. It is also expressed in several differentiated epithelial and non-epithelial cells.
PROM1; PROML1; MSTP061; Prominin-1; AC133
(1) Thamm K, Šimaitė D, Karbanová J, Bermúdez V, Reichert D, Morgenstern A, Bornhäuser M, Huttner WB, Wilsch-Bräuninger M, Corbeil D. Prominin-1 (CD133) modulates the architecture and dynamics of microvilli. Traffic. 2019 Jan;20(1):39-60. doi: 10.1111/tra.12618. Epub 2018 Nov 14. PMID: 30328220.
(2) Lee H, Yu DM, Bahn MS, Kwon YJ, Um MJ, Yoon SY, Kim KT, Lee MW, Jo SJ, Lee S, Koo SH, Jung KH, Lee JS, Ko YG. Hepatocyte-specific Prominin-1 protects against liver injury-induced fibrosis by stabilizing SMAD7. Exp Mol Med. 2022 Aug;54(8):1277-1289. doi: 10.1038/s12276-022-00831-y. Epub 2022 Aug 29. PMID: 36038590; PMCID: PMC9440255.
