CDH-CM103-100μg / 询价
CDH-CM103-500μg / 询价
CDH-CM103-500μgx2 / 询价
表达区间及表达系统(Source)
|
Recombinant Cynomolgus CDH3/Cadherin 3 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Asp108-Gly654 [Accession | XP_005592414.1]. |
分子量大小(Molecular Weight)
|
The protein has a predicted MW of 61.11 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result. |
纯度(Purity)
|
> 95% as determined by Bis-Tris PAGE |
内毒素(Endotoxin)
|
Less than 1EU per μg by the LAL method. |
制剂(Formulation)
|
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
重构方法(Reconstitution)
|
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
存储(Storage)
|
-20 to -80°C for 12 months as supplied from date of receipt. |
Recombinant Cynomolgus CDH3/Cadherin 3 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Asp108-Gly654 [Accession | XP_005592414.1].
The protein has a predicted MW of 61.11 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
Less than 1EU per μg by the LAL method.
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been proved it could be a serum marker to monitor colorectal cancer. Inhibited CDH3 expression could upregulate E-cadherin, downregulated N-cadherin, which may control invasion and migration.
Cadherin-3; Placental cadherin; P-cadherin; CDH3; CDHP; HJMD; PCAD; PCADP-cadherin; CAD3
(1) Zhou Y, Chi Y, Bhandari A, Xia E, Thakur PC, Qu J, Wang O, Zhang X. Downregulated CDH3 decreases proliferation, migration, and invasion in thyroid cancer. Am J Transl Res. 2020 Jun 15;12(6):3057-3067. PMID: 32655830; PMCID: PMC7344063.
CDH-CM103-100μg / 询价
CDH-CM103-500μg / 询价
CDH-CM103-500μgx2 / 询价
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