CDH-CM103 | 价格

CDH-CM103-100μg / 询价

CDH-CM103-500μg / 询价

CDH-CM103-500μgx2 / 询价

Cynomolgus CDH3/Cadherin 3 Protein

产品信息(Product Info)
表达区间及表达系统(Source)

Recombinant Cynomolgus CDH3/Cadherin 3 Protein is expressed from HEK293 with His tag at the C-Terminus.
It contains Asp108-Gly654 [Accession | XP_005592414.1].

分子量大小(Molecular Weight)

The protein has a predicted MW of 61.11 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result.

纯度(Purity)

> 95% as determined by Bis-Tris PAGE

内毒素(Endotoxin)

Less than 1EU per μg by the LAL method.

制剂(Formulation)

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

重构方法(Reconstitution)

Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

存储(Storage)

-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

产品数据(Assay Data)
Bis-Tris PAGE

Cynomolgus CDH3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SPR Data

Anti-CDH3 Antibody captured on CM5 Chip via Protein A can bind Cynomolgus CDH3, His Tag with an affinity constant of 0.37 μM as determined in SPR assay (Biacore T200).

背景(Background)

Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been proved it could be a serum marker to monitor colorectal cancer. Inhibited CDH3 expression could upregulate E-cadherin, downregulated N-cadherin, which may control invasion and migration.

分子别名(Synonyms)

Cadherin-3; Placental cadherin; P-cadherin; CDH3; CDHP; HJMD; PCAD; PCADP-cadherin; CAD3

文献(References)

(1) Zhou Y, Chi Y, Bhandari A, Xia E, Thakur PC, Qu J, Wang O, Zhang X. Downregulated CDH3 decreases proliferation, migration, and invasion in thyroid cancer. Am J Transl Res. 2020 Jun 15;12(6):3057-3067. PMID: 32655830; PMCID: PMC7344063.