CDH-HM1D1 | 价格

CDH-HM1D1-100μg / 询价

CDH-HM1D1-500μg / 询价

CDH-HM1D1-500μgx2 / 询价

Human CDH17/Cadherin 17 Domain 1-6 Protein

产品信息(Product Info)
表达区间及表达系统(Source)

Recombinant Human CDH17/Cadherin 17 Domain 1-6 Protein is expressed from HEK293 with His tag at the C-Terminus.
It contains Gln23-Leu667 [Accession | Q12864].

分子量大小(Molecular Weight)

The protein has a predicted MW of 72.90 kDa. Due to glycosylation, the protein migrates to 90-110 kDa based on Bis-Tris PAGE result.

纯度(Purity)

> 95% as determined by Bis-Tris PAGE

内毒素(Endotoxin)

Less than 1EU per μg by the LAL method.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in 20mM Tris, 150mM NaCl (pH 8.0).. Normally 8% trehalose is added as protectant before lyophilization.

重构方法(Reconstitution)

Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

存储(Storage)

-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

产品数据(Assay Data)
Bis-Tris PAGE

Human CDH17 Domain 1-6 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

ELISA Data

Immobilized Human CDH17 Domain 1-6, His Tag at 1μg/ml (100μl/Well) on the plate. Dose response curve for Anti-CDH17 Anitibody, hFc Tag with the EC50 of 8.9ng/ml determined by ELISA (QC Test).

背景(Background)

Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.

分子别名(Synonyms)

Cadherin-17; BILL-cadherin; LI-cadherin; P130; Cdh17; CDH16; HPT-1; cadherin-16; FLJ26931; MGC138218; MGC142024

文献(References)

(1) Liu X, Huang Y, Yuan H, Qi X, Manjunath Y, Avella D, Kaifi JT, Miao Y, Li M, Jiang K, Li G. Disruption of oncogenic liver-intestine cadherin (CDH17) drives apoptotic pancreatic cancer death. Cancer Lett. 2019 Jul 10;454:204-214. doi: 10.1016/j.canlet.2019.04.022. Epub 2019 Apr 17. PMID: 31004701.