货号价格

CLD-CM006-100μg / 询价

CLD-CM006-100μg x 5 / 询价

CLD-CM006-100μg x 10 / 询价

Cynomolgus Claudin 6 Protein-VLP

产品信息(Product Info)
表达区间及表达系统(Source)

Recombinant Cynomolgus Claudin 6 Protein-VLP is expressed from HEK293. It contains Met1-Val220.[Accession | G7Q0B0]

分子量大小(Molecular Weight)

The target protein has a predicted MW of 24.60 kDa.

内毒素(Endotoxin)

Less than 1EU per μg by the LAL method.

纯度(Purity)

> 95% as determined by HPLC

制剂(Formulation)

Supplied as 0.22μm filtered solution in PBS, 300mM L-Arginine (pH 7.4). Notice: If you need it for immunization, Do Not use any adjuvant.

存储(Storage)

Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

产品数据(Assay Data)
SEC-HPLC

The purity of Cynomolgus Claudin 6 VLP is greater than 95% as determined by SEC-HPLC.

ELISA Data

Immobilized Cynomolgus Claudin 6 VLP at 5μg/ml (100μl/Well) on the plate. Dose response curve for Anti-Claudin6 Antibody, mFc Tag with the EC50 of 4ng/ml determined by ELISA (QC Test).

背景(Background)

Claudin-6 is a multipass transmembrane protein in the Claudin family. Claudin-6 is expressed by epithelial cells where it participates in tissue development and the maintenance of tight junction integrity. Human Claudin-6 shares 88% and 86% amino acid sequence identity with mouse and rat Claudin-6, respectively.

分子别名(Synonyms)

Claudin-6; Skullin; CLDN6; Claudin6; Skullin 2; EGM_11390; Claudin

文献(References)

(1) Sugimoto K, Ichikawa-Tomikawa N, Kashiwagi K, Endo C, Tanaka S, Sawada N, Watabe T, Higashi T, Chiba H. Cell adhesion signals regulate the nuclear receptor activity. Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24600-24609. doi: 10.1073/pnas.1913346116. Epub 2019 Nov 18. PMID: 31740618; PMCID: PMC6900646.