货号价格

CLD-HE1822-100μg / 询价

CLD-HE1822-100μg x 5 / 询价

CLD-HE1822-100μg x 10 / 询价

Human Claudin 18.2 Protein-VLP

产品信息(Product Info)
表达区间及表达系统(Source)

Full length Human Claudin 18.2 Protein-VLP is expressed from HEK293. It contains Met1-Val261.[Accession | P56856-2]

分子量大小(Molecular Weight)

The target protein has a predicted MW of 29 kDa.

内毒素(Endotoxin)

Less than 1EU per μg by the LAL method.

纯度(Purity)

> 95% as determined by HPLC

制剂(Formulation)

Supplied as 0.22μm filtered solution in PBS, 300mM L-Arginine (pH 7.4). Notice: If you need it for immunization, Do Not use any adjuvant.

存储(Storage)

Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

产品数据(Assay Data)
SEC-HPLC

The purity of Human Claudin 18.2 VLP is greater than 95% as determined by SEC-HPLC.

ELISA Data

Immobilized Human Claudin 18.2 VLP at 5μg/ml (100μl/Well). Dose response curve for Anti-Claudin 18.2 Antibody, hFc Tag with the EC50 of 9.8ng/ml determined by ELISA (QC Test).

背景(Background)

Claudin18(CLDN18) belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells.CLDN18 is specifically expressed in the stomach and lung. CLDN18 has two alternatively spliced variants,CLDN18.1 and CLDN18.2. Isoform 2 (Claudin 18.2) is abundant in gastric tumors.

分子别名(Synonyms)

CLDN18; CLDN18.2; Claudin-18.2; Claudin18.2; Claudin-18; DKFZp564B2062; SFTA5; SFTPJ

文献(References)

(1)Singh P , Toom S , Huang Y. Anti-claudin 18.2 antibody as new targeted therapy for advanced gastric cancer[J]. Journal of Hematology & Oncology, 2017, 10(1):105.