Biotinylated Human Claudin 18.2 Protein-VLP
Recombinant Biotinylated Full length Human Claudin 18.2 Protein-VLP is expressed from HEK293.It contains Met1-Val261 [Accession | P56856-2].
The target protein has a predicted MW of 29 kDa.
> 95% as determined by HPLC
Less than 1EU per μl by the LAL method.
Supplied as 0.22μm filtered solution in PBS, 300mM L-Arginine (pH 7.4).
Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
The purity of Biotinylated Human Claudin 18.2 VLP is greater than 95% as determined by SEC-HPLC.
Biotinylated Human Claudin18.2 VLP captured on CM5 Chip via Streptavidin can bind Anti-Claudin18.2 Antibody with an affinity constant of 1.28 nM as determined in SPR assay (Biacore T200) (QC Test).
Claudin18(CLDN18) belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells.CLDN18 is specifically expressed in the stomach and lung. CLDN18 has two alternatively spliced variants,CLDN18.1 and CLDN18.2. Isoform 2 (Claudin 18.2) is abundant in gastric tumors.
CLDN18; CLDN18.2; Claudin-18.2; Claudin18.2; Claudin-18; DKFZp564B2062; SFTA5; SFTPJ
(1)Singh P , Toom S , Huang Y. Anti-claudin 18.2 antibody as new targeted therapy for advanced gastric cancer[J]. Journal of Hematology & Oncology, 2017, 10(1):105.
