CLD-HM14NB-100μg / 询价
CLD-HM14NB-100μgx5 / 询价
CLD-HM14NB-100μgx10 / 询价
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Biotinylated Human Claudin 4 Nanodisc
Recombinant Biotinylated Human Claudin 4 Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Val209 [Accession | O14493].
The protein has a predicted MW of 35.0 kDa.
Less than 1 EU per μg by the LAL method.
Supplied as 0.22 μm filtered solution in PBS, 200mM L-Arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
Valid for 6 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized Biotinylated Human Claudin 4 Nanodisc, His Tag at 5μg/ml (100μl/well) on the streptavidin precoated plate (5μg/ml). Dose response curve for Anti-Claudin 4 Antibody, hFc Tag with the EC50 of 6.6ng/ml determined by ELISA (QC Test).
Biotinylated Human Claudin 4 Nanodisc, His Tag captured on CM5 Chip via Streptavidin can bind Anti-Claudin 4 Antibody, hFc Tag with an affinity constant of 6.145 nM as determined in SPR assay (Biacore T200).
Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs into tumors.
Claudin-4; CLDN4; Claudin4; CPE-R; CPE R; CPETR1; WBSCR8
Fujiwara-Tani R, Mori S, Ogata R, Sasaki R, Ikemoto A, Kishi S, Kondoh M, Kuniyasu H. Claudin-4: A New Molecular Target for Epithelial Cancer Therapy. Int J Mol Sci. 2023 Mar 13;24(6):5494. doi: 10.3390/ijms24065494. PMID: 36982569; PMCID: PMC10051602.
