CR5-HM4N191B-100μg / 询价
CR5-HM4N191B-100μg x 5 / 询价
CR5-HM4N191B-100μg x 10 / 询价
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Biotinylated Human CCR5 Protein-Nanodisc
Recombinant Biotinylated Human CCR5 Protein-Nanodisc is expressed from HEK293 with His tag and Avi tag at the C-terminus.It contains Met1-Leu352 [Accession | P51681].
The protein has a predicted MW of 44.5 kDa.
Less than 1EU per μg by the LAL method.
Supplied as 0.22 μm filtered solution in PBS (pH 7.4). Notice: Not recommended for immunization.
Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized Biotinylated Human CCR5 Nanodisc, His Tag at 5μg/ml (100μl/well) on the streptavidin precoated plate (5μg/ml). Dose response curve for Anti-CCR5 Antibody, hFc Tag with the EC50 of 0.20μg/ml determined by ELISA (QC Test).
CC chemokine receptor 5 (CCR5) is a seven-transmembrane, G protein-coupled receptor (GPCR) which regulates trafficking and effector functions of memory/effector T-lymphocytes, macrophages, and immature dendritic cells. It also serves as the main coreceptor for the entry of R5 strains of human immunodeficiency virus (HIV-1, HIV-2). Chemokine binding to CCR5 leads to cellular activation through pertussis toxin-sensitive heterotrimeric G proteins as well as G protein-independent signalling pathways.
C-C CKR-5; CC-CKR-5; CCR-5; CHEMR13; CD195; CMKBR5
Oppermann M. Chemokine receptor CCR5: insights into structure, function, and regulation. Cell Signal. 2004 Nov;16(11):1201-10. doi: 10.1016/j.cellsig.2004.04.007. PMID: 15337520.
