CR8-HM1N29-100μg / 询价
CR8-HM1N29-100μg x 5 / 询价
CR8-HM1N29-100μg x 10 / 询价
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Human CCR8 Protein-Nanodisc
Recombinant Human CCR8 Protein-Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Leu355 [Accession | P51685-1].
The protein has a predicted MW of 42.60 kDa.
Less than 1EU per μg by the LAL method.
Supplied as 0.22 μm filtered solution in PBS (pH 7.4). Notice: Not recommended for immunization.
Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized Human CCR8 Nanodisc, His Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Anti-CCR8 Antibody, hFc Tag with the EC50 of 10.2ng/ml determined by ELISA (QC Test).
Human CCR8 nanodisc, His Tag captured on CM5 Chip via Anti-His Antibody can bind Anti-CCR8 Antibody, hFc Tag with an affinity constant of 53.40 pM as determined in SPR assay (Biacore T200).
CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and thymic cell line apoptosis and is alternative coreceptor with CD4 for HIV-1 infection.
CCR-8; CMKBRL2; CKR-L1; GPR-CY6; GPRCY6; TER1; CCR8; CKRL1; CMKBR8; CD198; ChemR1; CKR-L1; CY6; TER-1; CDw198
(1) Berenguer J, Lagerweij T, Zhao XW, Dusoswa S, van der Stoop P, Westerman B, de Gooijer MC, Zoetemelk M, Zomer A, Crommentuijn MHW, Wedekind LE, López-López À, Giovanazzi A, Bruch-Oms M, van der Meulen-Muileman IH, Reijmers RM, van Kuppevelt TH, García-Vallejo JJ, van Kooyk Y, Tannous BA, Wesseling P, Koppers-Lalic D, Vandertop WP, Noske DP, van Beusechem VW, van Rheenen J, Pegtel DM, van Tellingen O, Wurdinger T. Glycosylated extracellular vesicles released by glioblastoma cells are decorated by CCL18 allowing for cellular uptake via chemokine receptor CCR8. J Extracell Vesicles. 2018 Mar 13;7(1):1446660.
