CXC-HM1R5-100μg / 询价
CXC-HM1R5-100μgx5 / 询价
CXC-HM1R5-100μgx10 / 询价
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Human CXCR5 VLP
Recombinant Human CXCR5 VLP is expressed from HEK293.It contains Met1-Phe372 (It may have cross reaction with anti-His antibody) [Accession | P32302-1].
The protein has a predicted MW of 54.90 kDa.
> 95% as determined by HPLC
Less than 1 EU per μg by the LAL method.
Supplied as 0.22 μm filtered solution in PBS, 150mM L-Arginine (pH 7.4). Notice: If you need it for immunization, water-soluble adjuvant is recommended.
Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
The purity of Human CXCR5 VLP is greater than 95% as determined by SEC-HPLC.
Immobilized Human CXCR5 VLP at 5μg/ml (100μl/well) on the plate. Dose response curve for Anti-CXCR5 Antibody, hFc Tag with the EC50 of 71.7ng/ml determined by ELISA (QC Test).
CXCR5 is a serpentine receptor implicated in cell migration in lymphocytes and differentiation in leukocytes. It causes MAPK pathway activation and has known membrane partners for signaling. CXCR5 is also expressed in HL-60 cells, a human acute myeloid leukemia line, following treatment with all-trans retinoic acid, which induces differentiation toward a neutrophil-like state. CXCR5 is necessary for this process; differentiation was crippled in CXCR5 knockout cells and enhanced in cells ectopically expressing it.
CXC-R5; CXCR-5; MDR-15; MDR15; CD185; BLR1
MacDonald RJ, Yen A. CXCR5 overexpression in HL-60 cells enhances chemotaxis toward CXCL13 without anticipated interaction partners or enhanced MAPK signaling. In Vitro Cell Dev Biol Anim. 2018 Dec;54(10):725-735. doi: 10.1007/s11626-018-0293-z. Epub 2018 Oct 1. Erratum in: In Vitro Cell Dev Biol Anim. 2020 Oct;56(9):825. doi: 10.1007/s11626-020-00510-0. PMID: 30276608; PMCID: PMC6657802.
