CXR-HM00V-100μg / 询价
CXR-HM00V-100μgx5 / 询价
CXR-HM00V-100μgx10 / 询价
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Human CX3CR1 VLP
Recombinant Human CX3CR1 VLP is expressed from HEK293.It contains Met1-Leu355 (It may have cross reaction with anti-His antibody) [Accession | P49238-1].
The target protein has a predicted MW of 41.6 kDa.
> 90% as determined by HPLC
Less than 1 EU per μg by the LAL method.
Supplied as 0.22μm filtered solution in PBS, 150mM L-Arginine (pH 7.4). Notice: If you need it for immunization, water-soluble adjuvant is recommended.
Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
The purity of Human CX3CR1 VLP is greater than 90% as determined by SEC-HPLC.
Immobilized Human CX3CR1 VLP at 5μg/ml (100μl/well) on the plate. Dose response curve for Anti-CX3CR1 Antibody, hFc Tag with the EC50 of 1.4ng/ml determined by ELISA (QC Test).
CX3CR1, also known as G-protein coupled receptor 13, is a receptor of CX3CL1. It is primarily expressed on monocytes, macrophages, dendritic cells, T cells, and natural killer cells. The binding of CX3CL1 to CX3CR1 induces the activation of heterotrimeric G proteins associated with this receptor. In addition, it triggers the signal pathways of MAPK and AKT, which play essential roles in tumour biology.
CX3C chemokine receptor 1; C-X3-C CKR-1; CMK-BRL-1; CMK-BRL1; V28; CMKBRL1; GPR13; GPRV28
Lu X. Structure and Function of Ligand CX3CL1 and its Receptor CX3CR1 in Cancer. Curr Med Chem. 2022;29(41):6228-6246. doi: 10.2174/0929867329666220629140540. PMID: 35770395.
