CXR-HM1RNB-100μg / 询价
CXR-HM1RNB-100μgx5 / 询价
CXR-HM1RNB-100μgx10 / 询价
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Biotinylated Human CXCR4 Nanodisc
Recombinant Biotinylated Human CXCR4 Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Ser352 [Accession | P61073-1].
The protein has a predicted MW of 52.60 kDa.
Less than 1 EU per μg by the LAL method.
Supplied as 0.22 μm filtered solution in PBS (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
Valid for 6 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized Biotinylated Human CXCR4 Nanodisc, His Tag at 5μg/ml (100μl/well) on the streptavidin precoated plate (5μg/ml). Dose response curve for Anti-CXCR4 Antibody, hFc Tag with the EC50 of 5.1ng/ml determined by ELISA (QC Test).
CXC chemokine receptor type 4 (CXCR4) is a member of the G protein-coupled receptors (GPCRs) superfamily and is specific for CXC chemokine ligand 12 (CXCL12, also known as SDF-1), which makes CXCL12/CXCR4 axis. CXCR4 interacts with its ligand, triggering downstream signaling pathways that influence cell proliferation chemotaxis, migration, and gene expression.
CXC-R4; CXCR-4; FB22; Fusin; HM89; LCR1; LESTR; LAP-3; NPYRL; NPYR; NPY3R; SDF-1 receptor; CD184; D2S201E; HSY3RR;
Bao S, Darvishi M, H Amin A, Al-Haideri MT, Patra I, Kashikova K, Ahmad I, Alsaikhan F, Al-Qaim ZH, Al-Gazally ME, Kiasari BA, Tavakoli-Far B, Sidikov AA, Mustafa YF, Akhavan-Sigari R. CXC chemokine receptor 4 (CXCR4) blockade in cancer treatment. J Cancer Res Clin Oncol. 2023 Aug;149(10):7945-7968. doi: 10.1007/s00432-022-04444-w. Epub 2023 Mar 11. PMID: 36905421.
