DLL-HM103-100μg / 询价
DLL-HM103-500μg / 询价
DLL-HM103-500μgx2 / 询价
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Human DLL3 Protein
Recombinant Human DLL3 Protein is expressed from HEK293 with His tag at the N-terminus.It contains Ala27-Arg490 [Accession | Q9NYJ7-1].
The protein has a predicted MW of 50.4 kDa. Due to glycosylation, the protein migrates to 52-60 kDa based on Bis-Tris PAGE result.
>95% as determined by Bis-Tris PAGE
Less than 1 EU per μg by the LAL method.
Lyophilized from 0.22 μm filtered solution in PBS, 200 mM Arginine (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human DLL3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
Immobilized Human DLL3, His Tag at 0.1 μg/mL (100 μl/well). Dose response curve for Anti-DLL3 Antibody, hFc Tag with the EC50 of 2.6 ng/ml determined by ELISA (QC Test).
Anti-DLL3 Antibody captured on CM5 Chip via Protein A can bind Human DLL3, His Tag with an affinity constant of 0.22 nM as determined in SPR assay (Biacore T200).
Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis and may be required to divert neurons along a specific differentiation pathway. It plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.
Delta3; DLL3; Pudgy; SCDO1; SCDO1delta3
(1) Saunders L R , Bankovich A J , Anderson W C , et al. A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo[J]. Science Translational Medicine, 2015.
