EGF-CM101-100μg / 询价
EGF-CM101-500μg / 询价
EGF-CM101-500μgx2 / 询价
Rhesus macaque EGFR/HER1 Protein
Recombinant Rhesus macaque EGFR/HER1 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Leu25-Ser645.[Accession | P55245]
The protein has a predicted MW of 69.8 kDa. Due to glycosylation, the protein migrates to 85-100 kDa based on Tris-Bis PAGE result.
Less than 1EU per μg by the LAL method.
> 95% as determined by Tris-Bis PAGE
> 95% as determined by HPLC
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3-6 months after reconstitution.
2-8°C for 2-7 days after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Rhesus macaque EGFR on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
The purity of Rhesus macaque EGFR is greater than 95% as determined by SEC-HPLC.
Immobilized Rhesus macaque EGFR, His Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Human EGF, hFc Tag with the EC50 of 5.9ng/ml determined by ELISA.
The epidermal growth factor receptor is a transmembrane protein that is a receptor for members of the epidermal growth factor family of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR, HER2/neu, Her 3 and Her 4. Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses.
ErbB; EC 2.7.10; EC 2.7.10.1; EGFR; mENA; LEGFR; ERBB; ERBB1; HER1; PIG61; NISBD2
(1)Seshacharyulu P , Ponnusamy M P , Haridas D , et al. Targeting the EGFR signaling pathway in cancer therapy[J]. Expert Opinion on Therapeutic Targets, 2012.
