FGF-HM2R4-100μg / 询价
FGF-HM2R4-500μg / 询价
FGF-HM2R4-500μgx2 / 询价
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Human FGFR4 Protein
Recombinant Human FGFR4 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Leu22-Asp369 [Accession | P22455].
The protein has a predicted MW of 65.3 kDa. Due to glycosylation, the protein migrates to 80-95 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Less than 1EU per μg by the LAL method.
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human FGFR4 on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.
The purity of Human FGFR4 is greater than 95% as determined by SEC-HPLC.
Human FGFR4, hFc Tag captured on CM5 Chip via Protein A can bind Human Beta Klotho, His Tag with an affinity constant of 13.05 nM as determined in SPR assay (Biacore T200).
Fibroblast growth factor receptor 4 (FGF R4), also known as CD334, is a 110 kDa glycosylated transmembrane receptor tyrosine kinase.Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19.
CD334; FGF R4; FGFR4; FGFR-4; MGC20292; JTK2; TKF
(1)Katoh, Masaru. FGFR inhibitors: Effects on cancer cells, tumor microenvironment and whole-body homeostasis (Review)[J]. International Journal of Molecular Medicine, 2016.
