FGL-CM211-100μg / 询价
FGL-CM211-500μg / 询价
FGL-CM211-500μgx2 / 询价
Cynomolgus FGL1 Protein
Recombinant Cynomolgus FGL1 Protein is expressed from HEK293 with hFc at the N-Terminus.It contains Leu23-Ile312 [Accession | G7N0K6-1].
The protein has a predicted MW of 55.5 kDa. Due to glycosylation, the protein migrates to 62-68 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Less than 1EU per μg by the LAL method.
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Cynomolgus FGL1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Cynomolgus FGL1 is greater than 95% as determined by SEC-HPLC.
Immobilized Human LAG3, His Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Cynomolgus FGL1, hFc Tag with the EC50 of 23.6ng/ml determined by ELISA (QC Test).
Fibrinogen-like protein 1 (FGL-1) is a protein that is structurally related to fibrinogen. In humans, FLG-1 is encoded by the FGL1 gene.Fibrinogen-like protein 1 is a member of the fibrinogen family of proteins, which also includes fibrinogen, fibrinogen-like protein 2, and clotting factors V, VIII, and XIII.Fibrinogen-like Protein 1 is a major immune inhibitory ligand of LAG-3.
FGL1; FGL-1; Hepassocin; HP-041; HFREP-1; LFIRE-1; HFREP1; Lag3 ligand
(1)Wang, J., Sanmamed, M.F., Datar, I., Su, T.T., Ji, L., Sun, J., Chen, L., Chen, Y., Zhu, G., Yin, W., et al. (2019). Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3. Cell 176, 334-347.e312.
