GMP-CKS-HE015-50μg / 询价
GMP-CKS-HE015-50μgx10 / 询价
GMP-CKS-HE015-50μgx20 / 询价
- 关联产品
- 客服电话
- 技术支持
GMP Human IL-15
Recombinant GMP Human IL-15 is expressed from E.coli without tag.It contains Asn49-Ser162 [Accession | P40933].
The protein has a predicted MW of 12.8 kDa same as Bis-Tris PAGE result.
≥ 95% as determined by SEC-HPLC.
≤ 0.01 EU per μg by the LAL method.
（Residual Host Cell Protein）
（Residual Host Cell DNA）
Lyophilized from 0.22 μm filtered solution in 20 mM Tris, 150 mM NaCl (pH 7.5). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
The product is shipped with ice bag. Store it immediately at -20°C±5°C upon arrival.
-20°C±5°C for 36 months in lyophilized state.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
GMP Human IL-15 on Bis-Tris PAGE under reduced condition.
Measured in a cell proliferation assay using CTLL-2 cells. The ED50 for this effect is 0.1 - 0.3 ng/mL. The specific activity of GMP Human IL-15 is > 1 × 10^7 IU/mg, which is calibrated against the human IL-15 WHO reference standard (NIBSC code: 95/554) (QC Test).
GMP Human IL-15 (reconstituted protein) was stored at 37°C, the protein is stable for 7 days determined by cell based assay.
GMP Human IL-15 (reconstituted protein) was stored at 4°C, the protein is stable for 90 days determined by cell based assay.
GMP Human IL-15 (reconstituted protein) was repeatedly frozen at -80°C and thawed at 37°C, the protein is stable after freezing and thawing 3 cycles determined by cell based assay.
KACTUS GMP Human IL-15 is manufactured according to GMP guidelines to ensure product quality and traceability. Our manufacturing site is ISO13485:2016 certified.
● Animal-free manufacturing, free from animal-derived facilities and materials.
● Comprehensive quality release testing, including purity, safety items (such as endotoxin, sterility, etc.) and bioactivity.
● Support documentation, including COA, COO, MSDS, TSE/BSE statement, etc. We can also provide other files with detailed information to support our customers at different stages of drug development.
IL-15 belongs to the common gamma chain cytokine family and has pleiotropic immunological functions, and the protein is mainly produced by monocytes, dendritic cells, and epithelial cells. IL-15 plays a crucial role in the development, homeostasis, and function of T, NK, and NK-T cells, and is additionally required for various functions of the B cells, dendritic cells (DC), macrophages, and mast cells. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA.
Interleukin-15; IL-15; IL15; il 15; MGC9721
(1)Lee H, Park SH, Shin EC. IL-15 in T-Cell Responses and Immunopathogenesis. Immune Netw. 2024 Feb 16;24(1):e11.
(2)Patidar M, Yadav N, Dalai SK. Interleukin 15: A key cytokine for immunotherapy. Cytokine Growth Factor Rev. 2016 Oct;31:49-59.
KACTUS GMP Human IL-15 is for research or ex vivo cell processing use, not for human or animal in vivo application.
