GPR-HM05P-100μg / 询价
GPR-HM05P-100μgx5 / 询价
GPR-HM05P-100μgx10 / 询价
Human GPRC5D VLP
Recombinant Human GPRC5D VLP is expressed from HEK293.It contains Met1-Val345 (It may have cross reaction with anti-His antibody) [Accession | Q9NZD1-1].
The target protein has a predicted MW of 39.6 kDa.
> 95% as determined by HPLC
Less than 1 EU per μg by the LAL method.
Supplied as 0.22 μm filtered solution in PBS, 300mM L-arginine (pH 7.4). Notice: If you need it for immunization, water-soluble adjuvant is recommended.
Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
G protein–coupled receptor, family C, group 5, member D (GPRC5D) is an orphan receptor that is primarily expressed in plasma cells and hard keratinized tissues, with low expression in normal human tissues. GPRC5D expression is enriched in malignant plasma cells and is associated with markers of high-risk myeloma.
GPRC5D; MGC129713; MGC129714; orphan G-protein coupled receptor
Chari A, Minnema MC, Berdeja JG, Oriol A, van de Donk NWCJ, Rodríguez-Otero P, Askari E, Mateos MV, Costa LJ, Caers J, Verona R, Girgis S, Yang S, Goldsmith RB, Yao X, Pillarisetti K, Hilder BW, Russell J, Goldberg JD, Krishnan A. Talquetamab, a T-Cell-Redirecting GPRC5D Bispecific Antibody for Multiple Myeloma. N Engl J Med. 2022 Dec 15;387(24):2232-2244. doi: 10.1056/NEJMoa2204591. Epub 2022 Dec 10. PMID: 36507686.
