HLG-HE41F-100μg / 询价
HLG-HE41F-500μg / 询价
HLG-HE41F-500μgx2 / 询价
Human HLA-G Free Heavy Chain Protein
Recombinant Human HLA-G Free Heavy Chain Protein is expressed from E.coli with His tag and Avi tag at the C-Terminus.It contains Gly25-Thr305(C66S) [Accession | P17693-1].
The protein has a predicted MW of 35.5 kDa. The protein migrates to 36-40 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
Less than 1EU per μg by the LAL method.
Supplied as 0.22μm filtered solution in 20mM Tris, 500mM NaCl, 20% Glycerol (pH 8.0).
Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human HLA-G Free heavy chain on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
Immobilized Human HLA-G Free Heavy Chain, His Tag at 2μg/ml (100μl/Well) on the. Dose response curve for Anti-HLA-G Antibody, hFc Tag with the EC50 of 29.0ng/ml determined by ELISA (QC Test).
Immobilized Human HLA-G Free Heavy Chain, His Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Human KIR2DL4, hFc Tag with the EC50 of 43.4ng/ml determined by ELISA.
HLA-G is a molecule that was first known to confer protection to the fetus from destruction by the immune system of its mother, thus critically contributing to fetal-maternal tolerance. The first functional finding constituted the basis for HLA-G research and can be summarized as such: HLA-G, membrane-bound or soluble, strongly binds its inhibitory receptors on immune cells (NK, T, B, monocytes/dendritic cells), inhibits the functions of these effectors, and so induces immune inhibition.
HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G
(1) Krijgsman D, Roelands J, Hendrickx W, Bedognetti D, Kuppen PJK. HLA-G: A New Immune Checkpoint in Cancer? Int J Mol Sci. 2020 Jun 25;21(12):4528. doi: 10.3390/ijms21124528. PMID: 32630545; PMCID: PMC7350262.
