IL1-MM1RB | 价格

IL1-MM1RB-100μg / 询价

IL1-MM1RB-500μg / 询价

IL1-MM1RB-500μgx2 / 询价

Mouse IL-17RB Protein

产品信息(Product Info)
表达区间及表达系统(Source)

Recombinant Mouse IL-17RB Protein is expressed from HEK293 with His tag at the C-Terminus.
It contains Arg18-Gly286 [Accession | Q9JIP3-1].

分子量大小(Molecular Weight)

The protein has a predicted MW of 30.9 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Bis-Tris PAGE result.

纯度(Purity)

> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC

内毒素(Endotoxin)

Less than 1EU per μg by the LAL method.

制剂(Formulation)

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

重构方法(Reconstitution)

Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

存储(Storage)

-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

产品数据(Assay Data)
Bis-Tris PAGE

Mouse IL-17RB on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC

The purity of Mouse IL-17RB is greater than 95% as determined by SEC-HPLC.

背景(Background)

Among inflammatory mediators, a growing body of evidence emphasizes the contribution of the interleukin 17 (IL-17) cytokine family in malignant diseases. Besides IL-17A, the prototypic member of the IL-17 family, several experimental findings strongly support the role of the IL-17B/IL-17 receptor B (IL-17RB) pathway in tumorigenesis and resistance to anticancer therapies. In mouse models, IL-17B signaling through IL-17RB directly promotes cancer cell survival, proliferation, and migration, and induces resistance to conventional chemotherapeutic agents.

分子别名(Synonyms)

IL-17 receptor B; IL-17RB; IL-17ER; Evi27; IL-17 RH1; IL-17ER; IL17RB

文献(References)

(1)Bastid J, Dejou C, Docquier A, Bonnefoy N. The Emerging Role of the IL-17B/IL-17RB Pathway in Cancer. Front Immunol. 2020 Apr 21;11:718. doi: 10.3389/fimmu.2020.00718. PMID: 32373132; PMCID: PMC7186465.

Note: HPLC results always come from liquid protein, due to absorption peak interference of trehalose in lyophilized powder.