ILR-HM221-100μg / 询价
ILR-HM221-500μg / 询价
ILR-HM221-500μgx2 / 询价
Human IL-21R Protein
Recombinant Human IL-21R Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Cys20-Pro236 [Accession | NP_068570.1].
The protein has a predicted MW of 51.8 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Less than 1EU per μg by the LAL method.
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human IL-21R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human IL-21R is greater than 95% as determined by SEC-HPLC.
Immobilized Human IL-21, No Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Human IL-21R, hFc Tag with the EC50 of 42.3ng/ml determined by ELISA.
IL-21 and IL-21R were highly expressed in the lesional skin and peripheral blood of psoriasis patients. IL-21 promoted CD4 T cells proliferation and Th17 cells differentiation and inhibiting Treg cells differentiation by upregulating RORγt expression and downregulating Foxp3 expression, with increased expression and secretion of IL-17A and IL-22.Microbial translocation and the associated immune activation during HIV-1 infection may lead to high expression levels of the IL-21R activation marker in RM B cells, a feature associated with increased apoptosis and a reduced number of these cells in the circulation.
IL-21 receptor; IL-21R; CD360; NILR
(1) Sammicheli S, Hejdeman B, Rethi B, Chiodi F. Immune activation and increased IL-21R expression are associated with the loss of memory B cells during HIV-1 infection. J Intern Med. 2012 Nov;272(5):492-503. doi: 10.1111/j.1365-2796.2012.02550.x. Epub 2012 Jun 15. PMID: 22530560.
