ITG-CM1V3-100μg / 询价
ITG-CM1V3-500μg / 询价
ITG-CM1V3-500μgx2 / 询价
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Cynomolgus Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein
Recombinant Cynomolgus Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Phe31-Pro993(ITGAV) acidic tail & Gly27-Asp718(ITGB3) basic tail [Accession | A0A2K5WCD3(ITGAV)&A0A2K5WYN9(ITGB3)].
The protein has a predicted MW of 112.31 kDa (ITGAV) & 81.27 kDa (ITGB3). Due to glycosylation, the protein migrates 95-140 to kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Less than 1EU per μg by the LAL method.
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Cynomolgus ITGAV&ITGB3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Cynomolgus ITGAV&ITGB3 is greater than 95% as determined by SEC-HPLC.
Immobilized Cynomolgus ITGAV&ITGB3, His Tag at 0.5μg/ml (100μl/Well) on the plate. Dose response curve for Anti-alpha V beta 3 Antibody, hFc Tag with the EC50 of 10.1ng/ml determined by ELISA.
ITGAV&ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV&ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV&ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling. ITGAV&ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV&ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling.
αVβ3; Integrin alpha V beta 3; beta3; alphaV; ITGAV&ITGB3;Integrin alpha V β 3; β3
(1)Morandi E M , Verstappen R , Zwierzina M E , et al. ITGAV and ITGA5 diversely regulate proliferation and adipogenic differentiation of human adipose derived stem cells[J]. Scientific Reports, 2016, 6(1):28889.
