ITG-HM461 | 价格

ITG-HM461-100μg / 询价

ITG-HM461-500μg / 询价

ITG-HM461-500μgx2 / 询价

Human Integrin alpha 6 beta 1 (ITGA6&ITGB1) Heterodimer Protein

产品信息(Product Info)
表达区间及表达系统(Source)

Recombinant Human Integrin alpha 6 beta 1 (ITGA6&ITGB1) Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.
It contains Phe24-Gly1012 (ITGA6) acidic tail and GIn21-Asp728 (ITGB1) basic tail [Accession | P23229-2 (ITGA6) & P05556-1 (ITGB1)].

分子量大小(Molecular Weight)

The protein has a predicted MW of 117.9 kDa (ITGA6) and 83.2 kDa (ITGB1). Due to glycosylation, the protein migrates to 140-160 kDa (ITGA6) and 110-150 kDa (ITGB1) under Non reducing (N) condition based on Bis-Tris PAGE result.

纯度(Purity)

> 95% as determined by Bis-Tris PAGE

内毒素(Endotoxin)

Less than 1 EU per μg by the LAL method.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

重构方法(Reconstitution)

Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

存储(Storage)

-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

产品数据(Assay Data)
Bis-Tris PAGE

Human ITGA6&ITGB1 on Bis-Tris PAGE under Non reducing (N) condition. The purity is greater than 95%.

背景(Background)

Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling

分子别名(Synonyms)

α6β1; Integrin alpha 6 beta 1; ITGA6&ITGB1;Integrin alpha 6 β 1

文献(References)

(1) Wewer U M , Shaw L M , Albrechtsen R , et al. The integrin alpha 6 beta 1 promotes the survival of metastatic human breast carcinoma cells in mice[J]. American Journal of Pathology, 1997, 151(5):1191-8.