ITG-HM4V3-100μg / 询价
ITG-HM4V3-500μg / 询价
ITG-HM4V3-500μgx2 / 询价
- 客服电话
- 技术支持
Human Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein
Recombinant Human Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Phe31-Val992(ITGAV) acidic tail & GLy27-Asp718(ITGB3) basic tail [Accession | P06756-1(ITGAV)&P05106-1(ITGB3)].
The protein has a predicted MW of 114 kDa (ITGAV) & 81.3 kDa (ITGB3). Due to glycosylation,the protein migrates to 85-140 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Less than 1EU per μg by the LAL method.
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human ITGAV&ITGB3 on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.
The purity of Human ITGAV&ITGB3 is greater than 95% as determined by SEC-HPLC.
Immobilized Human ITGAV&ITGB3, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Anti-alpha V beta3 Antibody, hFc Tag with the EC50 of 3.5ng/ml determined by ELISA.
ITGAV&ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV&ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV&ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling. ITGAV&ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV&ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling.
αVβ3; Integrin alpha V beta 3; beta3; alphaV; ITGAV&ITGB3;Integrin alpha V β 3; β3
(1)Morandi E M , Verstappen R , Zwierzina M E , et al. ITGAV and ITGA5 diversely regulate proliferation and adipogenic differentiation of human adipose derived stem cells[J]. Scientific Reports, 2016, 6(1):28889.
