ITG-MM2V3-100μg / 询价
ITG-MM2V3-500μg / 询价
ITG-MM2V3-500μgx2 / 询价
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Mouse Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein
Recombinant Mouse Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Phe31-Val988(ITGAV) acidic tail & Glu26-Asp717(ITGB3) basic tail [Accession | P43406(ITGAV)&O54890(ITGB3)].
The protein has a predicted MW of 131.48 kDa (ITGAV) & 101.58 kDa (ITGB3). Due to enzyme lysis and glycosylation, the protein migrates to 110-135 kDa and 50-60 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Less than 1EU per μg by the LAL method.
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Mouse ITGAV&ITGB3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Mouse ITGAV&ITGB3 is greater than 95% as determined by SEC-HPLC.
Mouse ITGAV&ITGB3, hFc Tag captured on CM5 Chip via Protein A can bind Human Vitronectin, His Tag with an affinity constant of 3.37 nM as determined in SPR assay (Biacore T200).
ITGAV&ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV&ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV&ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling. ITGAV&ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV&ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling.
αVβ3; Integrin alpha V beta 3; beta3; alphaV; ITGAV&ITGB3; Integrin alpha V β 3; β3
(1)Morandi E M , Verstappen R , Zwierzina M E , et al. ITGAV and ITGA5 diversely regulate proliferation and adipogenic differentiation of human adipose derived stem cells[J]. Scientific Reports, 2016, 6(1):28889.
