KLK-HM1B1-100μg / 询价
KLK-HM1B1-500μg / 询价
KLK-HM1B1-500μgx2 / 询价
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Human KLKB1 Protein
Recombinant Human KLKB1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gly20-Ala638 [Accession | P03952].
The protein has a predicted MW of 70.3 kDa. Due to glycosylation, the protein migrates to 72-80 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Less than 1EU per μg by the LAL method.
Lyophilized from 0.22μm filtered solution in 20mM NaAc,150mM NaCl (pH 5.0). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in 20mM NaAc,150mM NaCl (pH 5.0).
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human KLKB1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human KLKB1 is greater than 95% as determined by SEC-HPLC.
Measured by its ability to cleave a flourogenic peptide substrate Pro-Phe-Arg-7-amido-4-methylcoumarin (PFR-AMC). The specific activity is > 1000 pmol/min/μg.
Plasma kallikrein, also known as Fletcher factor or kallikrein B1 (KLKB1), is a serine endopeptidase, like its homologs tissue kallikrein and kallikrein-related peptidases (KLKs). Its physiological role is to catalyze the release of kinins and other vasoactive peptides.
Plasma kallikrein; PKK; KLK3; KLKB1; Fletcher factor; Kininogenin
(1) Adamopoulos PG, Kontos CK, Papageorgiou SG, Pappa V, Scorilas A. KLKB1 mRNA overexpression: A novel molecular biomarker for the diagnosis of chronic lymphocytic leukemia. Clin Biochem. 2015 Sep;48(13-14):849-54. doi: 10.1016/j.clinbiochem.2015.04.007. Epub 2015 Apr 17. PMID: 25891023.
