MR2-HM00V | 价格

MR2-HM00V-100μg / 询价

MR2-HM00V-100μgx5 / 询价

MR2-HM00V-100μgx10 / 询价

Human MRGPRX2 VLP

产品信息(Product Info)
表达区间及表达系统(Source)

Recombinant Human MRGPRX2 VLP is expressed from HEK293.
It contains Met1-Val330 (It may have cross reaction with anti-His antibody) [Accession | Q96LB1].

分子量大小(Molecular Weight)

The target protein has a predicted MW of 40.31 kDa.

纯度(Purity)

> 95% as determined by HPLC

内毒素(Endotoxin)

Less than 1 EU per μg by the LAL method.

制剂(Formulation)

Supplied as 0.22μm filtered solution in PBS, 300mM L-Arginine (pH 7.4). Notice: If you need it for immunization, water-soluble adjuvant is recommended.

存储(Storage)

Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

产品数据(Assay Data)
SEC-HPLC

The purity of Human MRGPRX2 VLP is greater than 95% as determined by SEC-HPLC.

ELISA Data

Immobilized Human MRGPRX2 VLP at 2μg/ml (100μl/well) on the plate. Dose response curve for Anti-MRGPRX2 Antibody, mFc Tag with the EC50 of 3.0ng/ml determined by ELISA. (QC Test)

背景(Background)

As receptor for multiple drugs, MRGPRX2 is crucial to drug-induced hypersensitivity. However, not only drugs, but also endogenous mediators like neuropeptides and host defense peptides activate MRGPRX2, suggesting its broad impact in cutaneous pathophysiology.

分子别名(Synonyms)

MRGX2

文献(References)

Wang Z, Babina M. MRGPRX2 signals its importance in cutaneous mast cell biology: Does MRGPRX2 connect mast cells and atopic dermatitis? Exp Dermatol. 2020 Nov;29(11):1104-1111. doi: 10.1111/exd.14182. Epub 2020 Sep 17. PMID: 32866307.