MR2-HM10XN-100μg / 询价
MR2-HM10XN-100μgx5 / 询价
MR2-HM10XN-100μgx10 / 询价
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表达区间及表达系统(Source)
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Recombinant Biotinylated Human MRGPRX2 Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Val330 [Accession | Q96LB1]. |
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分子量大小(Molecular Weight)
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The protein has a predicted MW of 50.1 kDa. |
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内毒素(Endotoxin)
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Less than 1 EU per μg by the LAL method. |
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制剂(Formulation)
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Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells. |
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存储(Storage)
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Valid for 6 months from date of receipt when stored at -80°C. |
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阴性对照
(Recommended Negative Control)
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CON-HM1NB |
Our Styrene-Maleic Anhydride(SMA) nanodisc platform delivers multi-pass transmembrane proteins exactly as they exist in the HEK293 cell membrane following recombinant expression— preserving their endogenous lipid environment and correct conformational states. Isolated directly from HEK293 cells via a gentle, detergent-free process, the multi-pass membrane proteins are subsequently encapsulated by SMA to ensure their stability. These uniform soluble nanoparticles eliminate extraction interferences while maintaining biological activity. Ensuring consistent performance from lot to lot, our nanodiscs provide the reliability and biological relevance essential for antibody screening and functional characterization in therapeutic antibody drug discovery and development, as assessed by SPR, BLI, ELISA, and other standard platforms.
❖ Correct structure & conformation
❖ Functional relevance ensured
❖ His-tag & biotinylation tag available
❖ Antibody screening
❖ Functional characterization(Molecular Level)
❖ Assay: SPR, BLI, ELISA
Recombinant Biotinylated Human MRGPRX2 Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Val330 [Accession | Q96LB1].
The protein has a predicted MW of 50.1 kDa.
Less than 1 EU per μg by the LAL method.
Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
Valid for 6 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
As receptor for multiple drugs, MRGPRX2 is crucial to drug-induced hypersensitivity. However, not only drugs, but also endogenous mediators like neuropeptides and host defense peptides activate MRGPRX2, suggesting its broad impact in cutaneous pathophysiology.
MRGX2
Wang Z, Babina M. MRGPRX2 signals its importance in cutaneous mast cell biology: Does MRGPRX2 connect mast cells and atopic dermatitis? Exp Dermatol. 2020 Nov;29(11):1104-1111. doi: 10.1111/exd.14182. Epub 2020 Sep 17. PMID: 32866307.
MR2-HM10XN-100μg / 询价
MR2-HM10XN-100μgx5 / 询价
MR2-HM10XN-100μgx10 / 询价
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