PAR-HM01R-100μg / 询价
PAR-HM01R-100μgx5 / 询价
PAR-HM01R-100μgx10 / 询价
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Human Proteinase-activated receptor 1/PAR-1 VLP
Recombinant Human Proteinase-activated receptor 1/PAR-1 VLP is expressed from HEK293.It contains Met1-Thr425 (It may have cross reaction with anti-His antibody) [Accession | P25116].
The protein has a predicted MW of 48.79 kDa.
> 95% as determined by HPLC
Less than 1 EU per μg by the LAL method.
Supplied as 0.22 μm filtered solution in PBS, 150mM L-Arginine (pH 7.4). Notice: If you need it for immunization, water-soluble adjuvant is recommended.
Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
The purity of Human PAR-1 VLP is greater than 95% as determined by SEC-HPLC.
Immobilized Human PAR-1 VLP at 5μg/ml (100μl/well) on the plate. Dose response curve for Anti-PAR-1 Antibody, hFc Tag with the EC50 of 5.0ng/ml determined by ELISA (QC Test).
Proteinase activated receptors (PAR 1-4) are membrane receptors with a unique way of activation by proteinases like thrombin, trypsin and matrix metalloproteinases which lead to a specific cellular response. PAR-1 was present in adenocarcinomas, melanomas, osteosarcomas, glioblastomas, meningiomas, leukaemias and squamous cell carcinomas. PAR-1 is widely expressed in human tumors suggesting an important role in tumorigenesis and providing potential targets for therapy.
Proteinase-activated receptor 1; PAR-1; Coagulation factor II receptor; Thrombin receptor; F2R; CF2R; PAR1; TR
Elste AP, Petersen I. Expression of proteinase-activated receptor 1-4 (PAR 1-4) in human cancer. J Mol Histol. 2010 Apr;41(2-3):89-99. doi: 10.1007/s10735-010-9274-6. Epub 2010 Jun 20. PMID: 20563836.
