PC2-HM10N-100μg / 询价
PC2-HM10N-100μgx5 / 询价
PC2-HM10N-100μgx10 / 询价
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Human PC2/Polycystin-2 Nanodisc
Recombinant Human PC2/Polycystin-2 Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Val968 [Accession | Q13563-1].
The protein has a predicted MW of 111.6 kDa.
Less than 1 EU per μg by the LAL method.
Supplied as 0.22 μm filtered solution in PBS (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
Valid for 6 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized Human PC2 Nanodisc, His Tag at 10μg/ml (100μl/well) on the plate. Dose response curve for Anti-PC2 Antibody, mFc Tag with the EC50 of 0.96μg/ml determined by ELISA (QC Test).
Polycystin-2 (PC2) is a calcium channel that can be found in the endoplasmic reticulum, the plasmatic membrane, and the primary cilium. Functions include receptor-operated, nonselective cation channel activity in the plasma membrane, intracellular Ca2+ release channel activity in the endoplasmic reticulum (ER), and mechanosensitive channel activity in the primary cilium of renal epithelial cells.
Polycystin-2; Polycystin 2; PC2; Polycystwin; R48321; PKD2; TRPP2
(1) Peña-Oyarzun D, Batista-Gonzalez A, Kretschmar C, Burgos P, Lavandero S, Morselli E, Criollo A. New emerging roles of Polycystin-2 in the regulation of autophagy. Int Rev Cell Mol Biol. 2020;354:165-186. doi: 10.1016/bs.ircmb.2020.02.006. Epub 2020 Mar 11. PMID: 32475472.
(2) Cantero MDR, Cantiello HF. Polycystin-2 (TRPP2): Ion channel properties and regulation. Gene. 2022 Jun 15;827:146313. doi: 10.1016/j.gene.2022.146313. Epub 2022 Mar 18. PMID: 35314260.
