PD1-CM201-100μg / 询价
PD1-CM201-500μg / 询价
PD1-CM201-500μgx2 / 询价
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关联产品
Cynomolgus PD-L2/B7-DC Protein
Biotinylated Human PD-L2/B7-DC Protein
Cynomolgus/Rhesus macaque PD-L1/B7-H1 Protein
Cynomolgus PD-L1/B7-H1 Protein
Biotinylated Cynomolgus/Rhesus macaque PD-L1/B7-H1 Protein (Primary Amine Labeling)
Biotinylated Human PD-L1/B7-H1 Protein
Biotinylated Mouse PD-L1/B7-H1 Protein (Primary Amine Labeling)
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Cynomolgus PD-1/PDCD1 Protein
Recombinant Cynomolgus PD-1/PDCD1 Protein is expressed from HEK293 with hFc tag at the C-Terminus. It contains Pro21-Gln167.[Accession | B0LAJ3]
The protein has a predicted MW of 42.4 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Tris-Bis PAGE result.
Less than 1EU per μg by the LAL method.
> 95% as determined by Tris-Bis PAGE
> 95% as determined by HPLC
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3-6 months after reconstitution.
2-8°C for 2-7 days after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Cynomolgus PD-1 on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%.
The purity of Cynomolgus PD-1 is greater than 95% as determined by SEC-HPLC.
Immobilized Cynomolgus PD-1, hFc Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Biotinylated Anti-PD1 Antibody, hFc Tag with the EC50 of 29.5ng/ml determined by ELISA (QC Test).
Cynomolgus PD-1, hFc Tag captured on CM5 Chip via Protein A can bind Cynomolgus PD-L1, His Tag with an affinity constant of 1.28 μM as determined in SPR assay (Biacore T200).
Programmed cell death protein 1, also known as PD-1 and CD279 , is a protein found on the surface of cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self tolerance by suppressing T cell inflammatory activity.
PDCD1; PD1; CD279; SLEB2; PD-1
(1)Blank C , Mackensen A. Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: an update on implications for chronic infections and tumor evasion[J]. Cancer Immunology Immunotherapy, 2007, 56(5):739-745.
