PRA-HM201 | 价格

PRA-HM201-100μg / 询价

PRA-HM201-500μg / 询价

PRA-HM201-500μgx2 / 询价

Human PILRA Protein

产品信息(Product Info)
表达区间及表达系统(Source)

Recombinant Human PILRA Protein is expressed from HEK293 with hFc tag at the C-Terminus.
It contains Gln20-Ala197 [Accession | Q9UKJ1-1].

分子量大小(Molecular Weight)

The protein has a predicted MW of 47 kDa. Due to glycosylation, the protein migrates to 60-68 kDa based on Bis-Tris PAGE result.

纯度(Purity)

> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC

内毒素(Endotoxin)

Less than 1EU per μg by the LAL method.

制剂(Formulation)

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

重构方法(Reconstitution)

Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

存储(Storage)

-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

产品数据(Assay Data)
Bis-Tris PAGE

Human PILRA on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC

The purity of Human PILRA is greater than 95% as determined by SEC-HPLC.

背景(Background)

Alzheimer's disease (AD) is a neurodegenerative disease characterized by a progressive decline in cognitive performance; Mild Cognitive Impairment (MCI) is instead an objective decline in cognitive performance that does not reach pathology. Paired immunoglobulin-like type 2 receptor alpha (PILRA) is a cell surface inhibitory receptor that was recently suggested to be involved in AD pathogenesis. In particular, the arginine-to-glycine substitution in position 78 (R78, rs1859788) was shown to be protective against AD.

分子别名(Synonyms)

PILRA; FDF03; PILRalpha; PILR-alpha

文献(References)

(1) Agostini S, Costa AS, Mancuso R, Guerini FR, Nemni R, Clerici M. The PILRA G78R Variant Correlates with Higher HSV-1-Specific IgG Titers in Alzheimer's Disease. Cell Mol Neurobiol. 2019 Nov;39(8):1217-1221. doi: 10.1007/s10571-019-00712-5. Epub 2019 Jul 11. PMID: 31297637.

Note: HPLC results always come from liquid protein, due to absorption peak interference of trehalose in lyophilized powder.