PSM-HM110-100μg / 询价
PSM-HM110-500μg / 询价
PSM-HM110-500μgx2 / 询价
- 关联产品
- 客服电话
- 技术支持
Human PSMA/FOLH1 Protein
Recombinant Human PSMA/FOLH1 Protein is expressed from HEK293 with His tag at the N-Terminus.It contains Lys44-Ala750 [Accession | Q04609-1].
The protein has a predicted MW of 80.6 kDa. Due to glycosylation, the protein migrates to 90-110 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Less than 1 EU per μg by the LAL method.
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human PSMA on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human PSMA is greater than 95% as determined by SEC-HPLC.
Immobilized Human PSMA, His Tag at 2μg/ml (100μl/Well) on the plate. Dose response curve for Anti-PSMA Antibody, hFc Tag with the EC50 of 4.1ng/ml determined by ELISA. (QC Test)
Loaded Anti-PSMA Ab., hFc Tag on ProA-Biosensor can bind Human PSMA, His Tag with an affinity constant of 1.74 nM as determined in BLI assay (Gator® Prime).
Prostate-specific membrane antigen (PSMA) is an enzyme that in humans is encoded by the FOLH1 (folate hydrolase 1) gene, also known as Glutamate carboxypeptidase II (GCPII). Human PSMA is highly expressed in the prostate, roughly a hundred times greater than in most other tissues. In some prostate cancers, PSMA is the second-most upregulated gene product, with an 8- to 12-fold increase over levels in noncancerous prostate cells.
GCP2; PSMA; PSMAFGCP; FGCP; Folate hydrolase 1; FOLHNAALADase I; GCPII; GCPIImGCP; NAALAD1; NAALADase I; NAALAdase; FOLH1; GIG27; PSM; FOLH; mGCP
(1)Song C , Francesca Z , Williams D G , et al. Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody-drug Conjugate Targeting PSMA, in Pre-clinical Models of Prostate Cancer[J]. Molecular Cancer Therapeutics, 2018:molcanther.0982.2017-.
