PVR-HM302-100μg / 询价
PVR-HM302-500μg / 询价
PVR-HM302-500μgx2 / 询价
Human PVRIG Protein
Recombinant Human PVRIG Protein is expressed from HEK293 with mFc (IgG2a) tag at the C-terminus.It contains Thr41-Asp171 [Accession | Q6DKI7].
The protein has a predicted MW of 40.03 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Bis-Tris PAGE result.
>95% as determined by Bis-Tris PAGE
>95% as determined by HPLC
Less than 1EU per μg by the LAL method.
Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human PVRIG on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human PVRIG is greater than 95% as determined by SEC-HPLC.
Immobilized Human Nectin-2, His Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Human PVRIG, mFc Tag with the EC50 of 92.1ng/ml determined by ELISA (QC Test).
Immobilized Human PVRIG, mFc Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-PVRIG Antibody, hFc Tag with the EC50 of 9.4ng/ml determined by ELISA.
Human PVRIG, mFc Tag captured on CM5 Chip via Protein A can bind Human Nectin-2, His Tag with an affinity constant of 87.49 nM as determined in SPR assay (Biacore T200).
Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family.PVRIG is a cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.
C7orf15; CD112R; MGC104322; MGC138297; MGC2463; PVRIG; ALS2CR18; ALS2CR9; LPD; PREL-2; PREL2; RalGDS/AF-6; RMO1
(1)PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8 T-cell Function. 2019.
