SEZ-CM106-100μg / 询价
SEZ-CM106-500μg / 询价
SEZ-CM106-500μgx2 / 询价
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Cynomolgus SEZ6 Protein
Recombinant Cynomolgus SEZ6 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Leu20-His927 [Accession | A0A2K5WPJ4].
The protein has a predicted MW of 99.11 kDa. Due to glycosylation, the protein migrates to 150-180 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Less than 1EU per μg by the LAL method.
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Cynomolgus SEZ6 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Cynomolgus SEZ6 is greater than 95% as determined by SEC-HPLC.
Immobilized Cynomolgus SEZ6, His Tag at 2μg/ml (100μl/Well) on the plate. Dose response curve for Anti-SEZ6 Antibody, hFc Tag with the EC50 of 4.5ng/ml determined by ELISA (QC Test).
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface.
SEZ-6; SEZ6; BSRPC; BSRP-C;
(1) Roitman M, Edgington-Mitchell LE, Mangum J, Ziogas J, Adamides AA, Myles P, Choo-Bunnett H, Bunnett NW, Gunnersen JM. Sez6 levels are elevated in cerebrospinal fluid of patients with inflammatory pain-associated conditions. Pain Rep. 2019 Mar 25;4(2):e719. doi: 10.1097/PR9.0000000000000719. PMID: 31041421; PMCID: PMC6455686.
