SIG-CM110-100μg / 询价
SIG-CM110-500μg / 询价
SIG-CM110-500μgx2 / 询价
- 关联产品
- 客服电话
- 技术支持
Cynomolgus Siglec-10 Protein
Recombinant Cynomolgus Siglec-10 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Thr17-Asn552 [Accession | A0A2K5WBX8].
The protein has a predicted MW of 59.90 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 90% as determined by HPLC
Less than 1EU per μg by the LAL method.
Supplied as 0.22μm filtered solution in 25mM MES, 150mM NaCl, 0.5M Arginine (pH 5.0).
Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Cynomolgus Siglec-10 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Cynomolgus Siglec-10 is greater than 90% as determined by SEC-HPLC.
Immobilized Cynomolgus Siglec-10, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Anti-Siglec-10 Antibody, hFc Tag with the EC50 of 17.7ng/ml determined by ELISA.
Siglec-10 is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab. It is also reported to bind to Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24 also known as HSA (Heat-stable antigen).Siglecs (sialic acid binding Ig-like lectins) are I-type lectins that belong to the immunoglobulin superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by a varying number of Ig-like C2-type domains. Siglecs 5-11 constitute the CD33/Siglec-3 related group, and are differentially expressed in the hematopoietic system.
SLG2; SIGLEC10; MGC126774; PRO940
(1) Barkal AA, et al.CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy.Nature. 2019 Jul 31. doi: 10.1038/s41586-019-1456-0.
