货号价格

SIG-HM222F-100μg / 询价

SIG-HM222F-500μg / 询价

SIG-HM222F-500μgx2 / 询价

FITC-Labeled Human Siglec-2/CD22 Protein

产品信息(Product Info)
表达区间及表达系统(Source)

Recombinant FITC-Labeled Human Siglec-2/CD22 Protein is expressed from HEK293 with hFc tag at the C-Terminus.
It contains Asp20-Arg687 [Accession | P20273-1].

分子量大小(Molecular Weight)

The protein has a predicted MW of 101.9 kDa. Due to glycosylation, the protein migrates to 130-140 kDa based on Bis-Tris PAGE result.

波长(Wavelength)

Excitation Wavelength: 490 nm

Emission Wavelength: 520 nm

纯度(Purity)

> 95% as determined by Bis-Tris PAGE

内毒素(Endotoxin)

Less than 1EU per μg by the LAL method.

制剂(Formulation)

Supplied as 0.22μm filtered solution in PBS (pH 7.4).

存储(Storage)

Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

产品数据(Assay Data)
Bis-Tris PAGE

FITC-Labeled Human Siglec-2/CD22 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

背景(Background)

CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice.

分子别名(Synonyms)

CD22 molecule; CD22; Siglec-2; B-cell receptor CD22; BL-CAM; SIGLEC2; SIGLEC2FLJ22814

文献(References)

(1)Kato J , Robert T. O'Donnell, Abuhay M , et al. Efficacy and toxicity of a CD22-targeted antibody-saporin conjugate in a xenograft model of non-Hodgkin's lymphoma[J]. OncoImmunology, 2012, 1(9):7.