SLC-HM15NB-100μg / 询价
SLC-HM15NB-100μgx5 / 询价
SLC-HM15NB-100μgx10 / 询价
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Biotinylated Human SLC15A4 Nanodisc
Our Styrene-Maleic Anhydride(SMA) nanodisc platform delivers multi-pass transmembrane proteins exactly as they exist in the HEK293 cell membrane following recombinant expression— preserving their endogenous lipid environment and correct conformational states. Isolated directly from HEK293 cells via a gentle, detergent-free process, the multi-pass membrane proteins are subsequently encapsulated by SMA to ensure their stability. These uniform soluble nanoparticles eliminate extraction interferences while maintaining biological activity. Ensuring consistent performance from lot to lot, our nanodiscs provide the reliability and biological relevance essential for antibody screening and functional characterization in therapeutic antibody drug discovery and development, as assessed by SPR, BLI, ELISA, and other standard platforms.
❖ Correct structure & conformation
❖ Functional relevance ensured
❖ His-tag & biotinylation tag available
❖ Antibody screening
❖ Functional characterization(Molecular Level)
❖ Assay: SPR, BLI, ELISA
Recombinant Biotinylated Human SLC15A4 Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Ala577 [Accession | Q8N697].
The protein has a predicted MW of 75.0 kDa.
Less than 1 EU per μg by the LAL method.
Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
Valid for 6 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
SLC15A4 is a member of the SLC15 family of solute carriers, which is an endolysosome-resident amino acid transporter in immune cells that mediates the transport of L-histidine, small peptides, and NOD1/NOD2 ligands. SLC15A4 plays a critical role in TLR7/8/9-induced immune responses through assembling a complex with the downstream adaptor TASL in a conformation-dependent manner. SLC15A4 represents a promising therapeutic target for the treatment of infections, tumors, and autoimmune diseases.
PHT1; PTR4; FP12591; HPHT1
Zhu Y, Zhang X, Zhang Q, Sun P, Liu K, Nie X, Ma J, Zhang L, Gao Y, Wang Y, Liu S, Gao A, Zhang L, Gao P. Development of conformation-selective antibodies targeting human SLC15A4. Nat Commun. 2025 Aug 8;16(1):7324. doi: 10.1038/s41467-025-62759-x. PMID: 40781080; PMCID: PMC12334626.
